The Advanced test analyses variants associated with monogenic inherited diseases, meaning conditions caused by a single gene: more than 150 health analyses for dogs and more than 55 for cats. Some examples include:
In dogs:
- Eyes: several forms of progressive retinal atrophy, primary open-angle glaucoma and primary lens luxation.
- Nervous system: degenerative myelopathy (SOD1 gene), neuronal ceroid lipofuscinosis and narcolepsy.
- Blood and clotting: von Willebrand disease, haemophilia A and B, and pyruvate kinase deficiency.
- Muscles and bones: exercise-induced collapse, centronuclear myopathy and osteogenesis imperfecta.
- Kidneys and metabolism: cystinuria, hyperuricosuria (SLC2A9 gene) and polycystic kidney disease.
In cats:
- Heart: hypertrophic cardiomyopathy (MYBPC3 gene), described in Maine Coons and Ragdolls.
- Kidneys: polycystic kidney disease and cystinuria.
- Blood: pyruvate kinase deficiency, haemophilia B and deficiencies of clotting factors XI and XII.
- Eyes and nervous system: progressive retinal atrophy, GM1 and GM2 gangliosidosis, and Niemann-Pick disease type C.
- Medications: sensitivity to certain medications.
See the full list for dogs and cats.
Many of these variants have been described in specific breeds. In other breeds or mixed-breed animals, their effects may differ or be less well studied. Furthermore, for certain conditions, such as degenerative myelopathy or feline hypertrophic cardiomyopathy, many animals carrying the variant never develop the disease, and most cats with hypertrophic cardiomyopathy do not carry the known variants. Therefore, your vet should assess each result in the context of your pet's health, and a favourable result does not replace any examinations they recommend, such as an echocardiogram.
Haven't taken the test yet? Choose the Advanced test for dogs or cats. If you already have the Starter test, you can unlock all these reports with the Advanced Upgrade, without sending another sample.