Cystinuria in Cats: Causes, Symptoms, and the Key Role of Genetics

Learn about cystinuria in cats, its symptoms, and how to prevent urinary stones. Detect the mutation in time with Koko Genetics' cat DNA test.

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Cistinuria en gatos: causas, síntomas y el papel clave de la genética

Cystinuria in cats is a hereditary metabolic disorder that prevents the proper renal reabsorption of cystine. This amino acid accumulates in the urine and precipitates, forming stones or gravel in the bladder and kidneys, compromising your feline's health.

Key Warning Signs

Cystine crystals irritate the urinary tract and can cause severe pain or urinary blockages. Consult a veterinarian if you detect:

  • Difficulty or visible pain when urinating.
  • Presence of blood in the urine (hematuria).
  • Frequent urination in very small amounts.
  • Constant licking of the genital area or meowing in pain.

Types of Cystinuria Analyzed by Koko Genetics

At Koko Genetics, we evaluate the specific genetic mutations that trigger the different variants of this disease:

  • Type B cystinuria (variant 1): This is the most common form. The cat needs to inherit two copies of the mutated gene (one from each parent) to develop the disease. Cats with only one copy are asymptomatic carriers.
  • Type B cystinuria (variant 2): Follows an autosomal recessive inheritance pattern associated with mutations in the SLC7A9 gene. To develop the disease, the cat must inherit a defective copy of the gene from each parent.
  • Type B cystinuria (variant 3): Like other type B variants, variant 3 follows an autosomal recessive inheritance pattern in the SLC7A9 gene. To manifest clinical disease, the cat must inherit a mutated copy from each parent.

The cat DNA test allows you to identify whether your feline has the type IA cystinuria variant or another type of mutation before stones form. Knowing their biological predisposition allows you to act in time alongside your veterinarian through:

  1. Increased hydration: Encouraging the intake of wet food and the use of water fountains.
  2. Urinary pH management: Adjusting the diet to prevent an overly acidic urinary environment.
  3. Regular check-ups: Monitoring urinary sediment through preventive testing.

Do not wait until your cat shows signs of pain or faces a costly veterinary emergency to take action. Prevention is the best tool to protect their health and ensure their quality of life.

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